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3 Bromoacetophenone Synthesis Essay

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Antiquity civilization essay irreverant reconstructing western, bromoacetophenone synthesis

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Synthesis of bromoacetophenone

Main Menu Synthesis of bromoacetophenone

At last,4'-Bromoacetophenone(99-90-1) safety, risk, hazard and MSDS. A fundamental starting material for organic synthesis. Usage Intermediates of Liquid Crystals. Sigma-Aldrich offers Sigma-Aldrich-77450, 2-Bromoacetophenone for your research needs. Find product specific information including CAS, MSDS, protocols and references. Standard Article. 3-Bromoacetophenone † Acetophenone, 3-bromo-D. E. Pearson, H. W. Pope, W. W. Hargrove; Published Online: 28 APR 2003 Buy ALPHA-BROMOACETOPHENONE at angenechem.com, Angene supplies ALPHA-BROMOACETOPHENONE at competitive price. Sigma-Aldrich offers Aldrich-B56404, 4′-Bromoacetophenone for your research needs. Find product specific information including CAS, MSDS, protocols and references. Abstract Guaiacyl, syringyl, and p-hydroxyphenyl-type bromoacetophenone derivatives were synthesized as the starting materials for β-O-4 type artificial lignin polymers. Synthesis description for preparation of BROMOACETOPHENONE. To the 25 g acetophenone and 125 g acetic acid while slowly 30 g bromine are added with vigorous stirring. Methods - Synthesis & Techniques Organic Syntheses Abstract;. Pearson, D. E. Pope, H. W. Hargrove, W. W. 2003. 3-Bromoacetophenone. Organic Syntheses. 7. Phenacyl bromide is the organic compound with the formula C 6 H 5 C(O)CH 2 Br. This colourless solid is a powerful lachrymator as well as a useful precursor to other. A practical and effective Z-selective synthesis of o-bromoacetophenone N-tosylhydrazones is developed. Subsequent cyclization of Z-tosylhydrazones to furnish 3-.

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Synthesis Of Chloropentamminecobalt 3 Chloride - Essay by Ambr

Synthesis Of Chloropentamminecobalt 3 Chloride Essay

Below is an essay on "Synthesis Of Chloropentamminecobalt 3 Chloride" from Anti Essays, your source for research papers, essays, and term paper examples.

Experiment 3
Title: Fluid Properties: Density and Viscosity
Date: 20th October 2011

Experimental Procedure:
Five liquids were tested for Density measurements. These liquids included Vegetable oil, corn syrup, shampoo and glycerol. For viscosity measurement only three liquids were tested such as shampoo, glycerol and vegetable oil.
Part I – Density Measurement
The density of the test fluid was found by weighing a known volume of the liquid using the graduated cylinder. The cylinder was weighed empty, and then graduated cylinder was filled to a certain volume according to the graduations on it and weighed again. The difference in weight was divided by the volume gives the weight per unit volume of the fluid. The liquid density was calculated.
The mass per unit volume, or the density, was thus measured in a direct way. [5]
Part II – Viscosity
The diameter and weight of five of the test spheres were measured and then the volume and density of each sphere were computed. Each sphere was dropped into the cylinder of each liquid and the time it takes for the sphere to fall a certain distance was measured (between the two labels on the cylinder). The distances between the labels were measured. The distance divided by the measured time gives the terminal velocity of the sphere. The measurements of the five spheres were repeated whose diameters and weights were determined earlier and the average of results were calculated. [5]

Results and Calculations:

Part I: Density Measurement

Table 1: Density Measurement
Test Fluid | Wt. of graduated Cylinder (g) | Volume of test fluid (ml) | Wt. Of Fluid & graduated cylinder (g) | *Mass of Fluid (g) |
Vegetable Oil | 68.86 | 30 | 110.36 | 41.50 |
Glycerol | 68.86 | 34 | 110.74 | 41.88 |
Shampoo | 69.46 | 36 | 106.87 | 37.41 |
Bath Cream | 83.83 | 46 | 133.44 | 49.61 |

*Mass of Fluid= (wt. of graduated cylinder) – (wt. of fluid & graduated cylinder).

Chemotherapeutics Laboratory Experiments Report Biology Essay

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About Us More About Us Chemotherapeutics Laboratory Experiments Report Biology Essay

Published: 23, March 2015

In order to perform Parallel synthesis and Biginelli reaction, firstly, 0.70gms 3-Chlorobenzyldehyde, 1.08gms alkyl acetoacetate, 0.37gms methyl urea and 2ml ethanol were added to a 7ml reaction tube containing a magnetic stirrer. Afterwards, 2-3 drops of conc. HCl were added (Use in Hood) into the mixture and the slurry refluxed in the Greenhouse Parallel reactor for 2 h. The reaction was cooled to 0oC and the resultant precipitate collected. For better precipitates, product may be further purified by recrystallization from ethanol.

Balanced reaction Scheme

1-(Aminocarbonyl)-6-(3-chlorophenyl)-1,2,3,6-tetrahydro-4-methyl-2-oxo-5-pyrimidinecarboxylic acid 1-methylethyl ester/ SQ 32926

Melting point: 94oC

NMR Data (Parallel Synthesis)

2.468 (1, 3H), 1.433 (2, 3H, J=6.904), 1.433 (3, 3H, d, J=6.904), 7.345 (9, 1H, J=8.085, J=8.057, J=4.353), 7.251 (10, 1H, J=8.057, J=1.671, J=1.561), 7.427 (11, 1H, J=8.085, J=1.671, J=1.501), 7.521 (12, 1H, J=4.353, J=1.561, J=1.501), 4.771 (22, 1H, J=6.904), 5.885 (23, 1H)

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For Biginelli reaction, 532mg benzaldehyde, 968µl ethyl acetoacetate, 370mg N-methyl urea and 5ml ethanol were added to a 50ml round bottom flask containing a magnetic stirrer. Further, 2-3 drops of conc. HCl were added and the mixture refluxed for 2 h. The reaction was cooled to 0oC and the resultant precipitate collected. For better precipitates, product may be further purified by recrystallization from ethanol.

Phenyl boronic acid

Warning about solvents

Irritant, Avoid skin, eye contact, harmful if inhaled etc.

Procedure

For Suzuki cross coupling reactions, 1gm of the aryl halide, 0.692gm of the arylboronic acid and 10ml of n-propanol were added to a 100ml round bottomed flask equipped with a magnetic stir bar and condenser. The condenser has been set up on the flask with attached balloon. Then, 7.2mg palladium acetate, 25.6mg triphenylphosphine as solid and 3.25ml 2M aqueous sodium carbonate were added along with 2ml deionised water. Allow the system to purge with nitrogen by slightly opening the flask/condenser joint for a few minutes. Heated the reaction to reflux under a nitrogen environment until approx. 3 hours.

At room temperature, 30ml water was added and mixture has stir for 5min. in the air. Then, reaction was diluted with 50ml ethyl acetate and transferred it to a separating funnel. Two layers were separated and aqueous layer has re-extracted with 50ml ethyl acetate. Afterwards, combine the organic extracts and wash them with a 5% sodium carbonate solution (2 - 20ml) and 10ml brine sequentially. Organic phase was then transferred to a conical flask equipped with a magnetic stir bar and 0.50gm activated charcoal and 1g sodium sulphate has been added. Slurry has stirred for 10min. then solution was filtered. Concentrate the resulting pale yellow filtrate under reduced pressure to yield the biaryl product as a solid. For crystals, slurry was washed with

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Molecular weight, number of moles of the reactants

(2R, 3R)-Tartaric acid Mw=150.0

-Methylbenzyl Amine Mw=121.18

Warning about solvents

Irritant, Avoid skin, eye contact, harmful if inhaled, use in fume hood etc.

Procedure

Part 1: (2R, 3R)-tartaric acid and methanol were added to a 100ml round bottom flask. Solution was heated with condenser for few minutes. Measured 1.40ml of racemic -Methylbenzyl Amine in to a small vial using a disposable syringe. Flask was removed from heating and then -Methylbenzyl Amine was slowly added with a Pasteur pipette. Slurry was again heated with condenser and was refluxed gently for

15 minutes. Solution then has positioned under room temperature and placed into the cupboard for 24 hours.

Part 2: less soluble diastereoisomer, (S)-ï€ ï¡-methylbenzylammonium hydrogen (2R,3R)-tartrate was collected, via vacuum filtration and the crystals were rinsed with about 5 mL of ice-cold methanol. Then crystals were transferred to a conical flask and water was added to dissolve the solid. Then dropwise 6M NaOH solution was added to dissolve the crystals. Organic layer has separated from separating funnel with diethyl ether. Combined organic layer then dried over magnesium sulphate and solution was filtered in pre-tared flask. Solvent was removed on the rotary evaporator and mass was recorded of the isolated amine.

To measure the Optical Rotation: -Methylbenzyl Amine and ethanol were weighted into a flask. Then sample placed into the polarimeter and rotation -- the sign (+ or -) and temperature were recorded. The specific rotation, []D Temp was calculated.

Specific rotation of the product: Optical rotation is measured with an instrument called a polarimeter. There is a linear relationship between the observed rotation and the concentration of optically active compound in the sample. There is a non-linear relationship between the observed rotation and the wavelength of light used. Specific rotation is calculated using either of two equations, depending on the sample you are measuring:

For pure liquids:

In this equation, l is the path length in decimeters, and ρ is the density of the liquid in g/mL, for a sample at a temperature T (given in degrees Celsius) and wavelength λ (in nanometers). The sign of the rotation (+ or -) is always given.

=-140 optical rotation, cell length 0.02 dm, sample 10 mg, in 10 ml solution. Optical rotation=-7000o cm3dm-1g-1[α]

Boiling point: 275oC

Balanced reaction Scheme

S-methyl benzyl amine

Synthesis and Study the Antimicrobial Activity of Novel 2-(1H-indol-3-yl)- N-(3, 4-diphenylthiazol-2(3H)-ylidene) Ethanamine Derivatives

Medicinal Chemistry Synthesis and Study the Antimicrobial Activity of Novel 2-(1H-indol-3-yl)- N-(3, 4-diphenylthiazol-2(3H)-ylidene) Ethanamine Derivatives

Affiliation: Division of Fluoroorganic, Indian Institute of Chemical Technology, Hyderabad-500607, India.

Abstract

A series of novel 2-(1H-indol-3-yl)-N-(3, 4-diphenylthiazol-2(3H)-ylidene) ethanamine derivatives (5a-o) were synthesized by cyclization of corresponding 1-(2-(1H-indol-3-yl) ethyl)-3-phenylthiourea 3 with 2-bromoacetophenone. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria and Gramnegative bacteria. In vitro antifungal activity also determined against the five fungal species. Structures of the synthesized compounds were established by elemental analysis and spectral data.

Z-Selective synthesis of o-bromoacetophenone N-tosylhydrazones and formation of 3-methylindazoles in aqueous ethanol

Z -Selective synthesis of o -bromoacetophenone N -tosylhydrazones and formation of 3-methylindazoles in aqueous ethanol
  • Tuula Kylmälä a ,
  • Sandra Udd b ,
  • Jan Tois a. . ,
  • Robert Franzén a
  • a Department of Chemistry and Bioengineering, Laboratory of Chemistry, Tampere University of Technology, Korkeakoulunkatu 8, 33720 Tampere, Finland
  • b Research and Development, Fermion Oy/Orion group, Koivu-Mankkaan tie 6 A, 02200 Espoo, Finland
Received 3 March 2010, Revised 26 April 2010, Accepted 7 May 2010, Available online 12 May 2010 Abstract

A practical and effective Z -selective synthesis of o -bromoacetophenone N -tosylhydrazones is developed. Subsequent cyclization of Z -tosylhydrazones to furnish 3-methylindazoles is accomplished with the aid of copper and DMEDA in aqueous ethanol. Cyclization reactions are complete at ambient temperature in 10 min to afford the desired compounds in excellent yields.

Graphical abstract

Characterization of Physico-Chemical and Spectroscopic Properties of Biofield Energy Treated 4-Bromoacetophenone

Characterization of Physico-Chemical and Spectroscopic Properties of Biofield Energy Treated 4-Bromoacetophenone

Mahendra Kumar Trivedi 1. Alice Branton 1. Dahryn Trivedi 1. Gopal Nayak 1. Gunin Saikia 2. Snehasis Jana 2. *

1 Trivedi Global Inc. Henderson, USA

2 Trivedi Science Research Laboratory Pvt. Ltd. Hall-A, Chinar Mega Mall, Chinar Fortune City, Hoshangabad Rd. Bhopal, Madhya Pradesh, India

To cite this article:

Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Gunin Saikia. Snehasis Jana. Characterization of Physico- Chemical and Spectroscopic Properties of Biofield Energy Treated 4- bromoacetophenone. American Journal of Physical Chemistry.Vol. 4. No. 4. 2015, pp. 30 - 37. doi: 10.11648/j.ajpc.20150404.11

Abstract: 4-Bromoacetophenone is an acetophenone derivative known for its usefulness in organic coupling reactions and various biological applications. The aim of the study was to evaluate the impact of biofield energy treatment on 4-bromoacetophenone using various analytical methods. The material is divided into two groups for this study i.e. control and treated. The control group remained as untreated and the treated group was subjected to Mr. Trivedi’s biofield energy treatment. Then, both the samples were characterized using X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), gas chromatography-mass spectrometry (GC-MS), and UV-visible spectrometry (UV-vis). The XRD study revealed that the crystallite size of treated 4-bromoacetophenone was decreased significantly to 16.69% with decreased intensity as compared to the control. The thermal studies revealed that the slight change was observed in the melting point and latent heat of fusion (ΔH) of biofield energy treated sample as compared to the control. Maximum degradation temperature (Tmax ) of treated 4-bromoacetophenone was decreased by 7.26% as compared to the control (169.89°C→157.54°C). The FT-IR spectra showed that the C=O stretching frequency at 1670 cm -1 was shifted to higher frequency region (1672 in T1 and 1685 cm -1 in T2, in two treated samples for FT-IR) after biofield energy treatment. Moreover, the GC-MS data revealed that the isotopic abundance ratio of either 13 C/ 12 C or 2 H/ 1 H (PM+1)/PM was decreased up to 9.12% in T2 sample whereas increased slightly up to 3.83% in T3 sample. However, the isotopic abundance ratio of either 81 Br/ 79 Br or 18 O/ 16 O (PM+2)/PM of treated 4-bromoacetophenone was decreased from 0.10% to 1.62% (where PM-primary mass of the molecule, (PM+1) and (PM+2) are isotopic mass of the molecule). The UV spectra showed the similar electronic behavior like absorption maximum in control and treated samples. Overall, the experimental results suggest that Mr. Trivedi’s biofield energy treatment has significant effect on the physical, thermal, and spectral properties of 4-bromoacetophenone.

Keywords: 4-Bromoacetophenone. Biofield Energy Treatment. Fourier Transform Infrared. Differential Scanning Calorimetry. Thermogravimetric Analysis. X-ray Diffraction, Gas Chromatography-Mass Spectrometry

4-Bromoacetophenone is basically a natural product and found in the environment as degradation products of industrial chemicals. It is used as a basic starting material in most of the metal catalyzed coupling reactions due to the presence of both electron-rich and electron-withdrawing functionalities within the same molecule [1 ]. In biological systems, halogen bonding has its importance due to their high directionality and specificity. Therefore, they can be used effectively in drug design to direct the binding of ligands to the target sites [2 ]. The bromoacetophenone derivatives upon excitation with ultraviolet radiation can generate phenyl radicals. The utility of haloarenes were studied by Paul et al. as radical progenitors for DNA cleavage. It is reported that haloarenes are readily available compounds upon UV excitation and halo acetophenones are effective DNA cleaving agents [3, 4]. 4-Bromoacetophenone has been used as basic starting material in coupling reactions such as Heck coupling, Suzuki coupling, and Stille reactions [5 ]. Furthermore, guaiacyl, syringyl, and p -hydroxyphenyl-type bromoacetophenone derivatives were synthesized as the starting materials for β-O -4 type artificial lignin polymers [6 ]. Apart from that, the acetophenones were screened for activity against positive phototaxis of Chlamydomonas cells, a process that requires coordinated flagellar motility. Several acetophenones including 3, 4-dimethylacetophenone, and 4-ethylacetophenone showed inhibitory effects on phototaxis in Chlamydomonas. in a concentration-dependent manner, indicating that these compounds nonspecifically interfere with phototaxis by disrupting overall cell viability [7 ].

Due to their wide range of applications in biology and synthetic organic chemistry, the objective of the current study was to evaluate the impact of biofield energy treatment on the physical and chemical properties of 4-bromoacetophenone. The biofield is defined as the complex dynamic electromagnetic (EM) field. The field resulting from the EM fields contributed by each individual oscillator or electrically charged ensemble of particles of the body (ion, molecule, cell, tissue, etc.) [8, 9]. The term "biofield" has been accepted by the U.S. National Library of Medicine as a medical subject heading [10 ]. The biofield, which surrounds the human body, can be harnessed from the Universe. It has been applied on materials or living things by experts in a controlled way to make the changes [11 ]. Mr. Trivedi’s unique biofield energy treatment is known as The Trivedi Effect ® [12 ]. The Trivedi Effect has been applied in various research fields including microbiology research [13 ], agriculture research [14, 15], and biotechnology research [16 ]. Thus, by observing the various transformations happened due to the unique biofield treatment of Mr. Trivedi, this study aimed to evaluate the impact of biofield energy treatment on 4-bromoacetophenone with respect to their physical, thermal and spectral properties.

2. Materials and Methods

2.1. Study Design

4-Bromoacetophenone was procured from Loba Chemie Pvt. Ltd. India. The compound was divided into two parts i.e. control and treated. The control sample was remained as untreated and the treated sample in sealed pack was given to Mr. Trivedi for biofield energy treatment. Mr. Trivedi provided the treatment through his energy transmission process to the treated group. The control and treated samples were evaluated using various physical, thermal and spectroscopic techniques.

Percent change in various parameters in treated sample with respect to control was calculated using the following equation:

2.2. X-ray Diffraction (XRD) Study

The X-ray powder diffraction studies were carried out to characterize the crystallinity of 4-bromoacetophenone using Phillips, Holland PW 1710 X-ray diffractometer system, with radiation of wavelength 1.54056 Å in the 2θ range 10°-99.99°. The crystallite size (G) was calculated by using the formula: G = kλ/(bCosθ). Here, λ is the wavelength of radiation, θ is the corresponding Bragg angle, b is full-width half maximum (FWHM) of the peaks and k is the equipment constant (=0.94).

2.3. Differential Scanning Calorimetry (DSC) Study

The DSC thermogram of 4-bromoacetophenone was acquired using Perkin Elmer/Pyris-1, USA at the flow rate of 5 mL/min using closed aluminum pan to determine the melting temperature and latent heat of fusion.

2.4. Thermogravimetric Analysis (TGA)/ Derivative Thermogravimetry (DTG)

TGA/DTG results were obtained using Mettler Toledo simultaneous thermogravimetric analyzer at a heating rate of 5ºC/min from room temperature to 400ºC under air atmosphere.

2.5. FT-IR Spectroscopic Analysis (FT-IR)

FT-IR characterization was done with Shimadzu Fourier transform infrared spectrometer (Japan) with the frequency range of 500-4000 cm -1. 4-bromoacetophenone was run as pressed disks using KBr as the diluent.

2.6. GC-MS Spectrometry Analysis

The gas chromatography-mass spectrometry (GC-MS) analysis was performed on Perkin Elmer/auto system XL with Turbo Mass, USA, having detection limit up to 1 picogram. The GC-MS spectrum was obtained as % abundance vs. mass to charge ratio (m/z ). The isotopic ratio of (PM+1)/PM and (PM+2)/PM was expressed by its deviation in treated samples as compared to the control.

2.7. UV-Vis Spectroscopic Analysis

UV-Vis spectra of control and treated samples were obtained from Shimadzu UV spectrophotometer (2400 PC) with quartz cell of 1 cm and a slit width of 2.0 nm. The analysis was done at the wavelength range of 200-400 nm.

3. Results and Discussion

The XRD study was conducted on both control and treated samples of 4-bromoacetophenone and diffractograms are shown in Figure 1. Both control and treated 4-bromoacetophenone samples exhibited very sharp and intense peaks of intensity 1350 a.u. and 630 a.u. respectively in their X-ray diffractogram. The control 4-bromoacetophenone exhibited the XRD peaks at 2θ equal to 19.05°, 28.71°, 38.57°, and 49.04° (Table 1). However, the XRD diffractogram of treated 4-bromoacetophenone showed the XRD peaks at 2θ equal to 18.91°, 20.45°, 23.28°, 28.57°, 38.46°, and 48.62 °, with decreased intensity as compared to the control. The crystallite size was calculated using Scherrer formula and found decreased after biofield treatment by 16.69% in the treated 4-bromoacetophenone. It was reported that the strain produced by energy milling had reduced the crystallite size in the crystal [17 ]. Thus, it is assumed that biofield energy treatment might induce the energy that causes milling in the treated 4-bromoacetophenone which is responsible for a decrease in crystallite size.

Table 1. XRD analysis of control and treated 4-bromoacetophenone.

3.3. TGA/DTG Analysis

The TGA/DTG thermograms of both control and treated samples of 4-bromoacetophenone are shown in Figure 2. TGA curve showed that the control and treated samples were degraded in one step. In control 4-bromoacetophenone, the onset temperature was at 128.69°C and endset at 199.86°C. However, in treated sample, onset temperature was observed at 124.95°C and endset at 186.66°C. In this process, the control sample lost 59.24% of its initial weight, whereas treated sample lost 57.44% of its initial weight. The DTG thermogram showed the Tmax at 169.89°C and 157.54°C, respectively in the control and treated sample. Thus, the decrease in maximum degradation temperature of treated 4-bromoacetophenone can be related to decreasing in thermal stability. The overall decreases in thermal stability of treated sample might be advantageous to be used as a reaction intermediate in coupling and photo excitation reactions.

Fig. 2. TGA-DTG thermogram of control and treated samples of 4-bromoacetophenone.

3.4. FT-IR Analysis

The treated sample of 4-bromoacetophenone was divided into two parts as T1, and T2. The FT-IR spectra of control and treated samples of 4-bromoacetophenone are presented in Figure 3. The FT-IR spectra showed the aromatic C-H stretching frequency at 3010 cm -1 for control and treated samples of 4-bromoacetophenone. The IR spectra of control 4-bromoacetophenone sample showed C=O stretching at 1670 cm -1. however in treated samples the C=O stretching frequency shifted to higher energy region (T1=1672 cm -1. T2=1685 cm -1 ). The carbon-halogen bond is stronger covalent bond and it can be easily identifiable and appeared at 609 cm -1. for the C−Br bending vibration in both control and treated samples. The absorption at 1587 cm -1 and 1359 cm -1 in control sample are due to the C=C stretching in aromatic ring (1359 cm -1 ) was first reduced to 1354 cm -1 and then increased to 1361 cm -1 in the treated T1 and T2 samples respectively. Furthermore, the C-H deformation bends were assigned to the peaks at 1269 cm -1 in both control and treated samples of 4-bromoacetophenone. The FT-IR spectra indicated that there was a slight alteration in the C=O and C=C stretching frequencies in the treated 4-bromoacetophenone, which increased after biofield energy treatment. The FT-IR results did not show any major changes in vibrational frequencies for the aromatic C-H stretching frequencies. The FT-IR spectral data is well matched with the literature data [18 ].

Fig. 3. FT-IR spectra of control and treated samples of 4-bromoacetophenone.

3.5. GC-MS Analysis

The treated sample of 4-bromoacetophenone was divided into four parts as T1, T2, T3, and T4. The mass spectra of control and treated samples of 4-bromoacetophenone are shown in Figure 4(a) and 4(b), respectively. The mass spectra showed the PM (primary molecule) peak at m/z = 198 in the control and treated samples of 4-bromoacetophenone. The m/z peak intensity, intensity ratio and isotopic abundance ratio of (PM+1)/PM and (PM+2)/PM peaks are presented in Table 3. There were six major peaks observed in both control and treated samples of 4-bromoacetophenone. The peaks are at m/z = 198, 183, 155, 76, 50 and 43 due to 4-bromoacetophenone and its degraded products. The degradation of 4-bromoacetophenone, corresponded to the following ions: C8 H9 Br + (p -bromoehtylbenzene), C6 H5 Br + (bromobenzene), C6 H5 + (benzene), C4 H2 + (1, 3-butadyine) and C2 H4 O + (acetaldehyde), respectively were well matched with the reported GC-MS data [19 ]. The treated 4-bromoacetophenone samples (T1-T4) were fragmented in a similar way with varied intensities as the control sample. Is otopic abundance ratio of (PM+1)/PM and (PM+2)/PM in 4-bromoacetophenone was calculated and presented in Figure 5. It is seen from the Figure 5 that the isotopic abundance ratio of (PM+1)/PM in 4-bromoacetophenone was increased by 3.83% in T3 sample, while it was decreased by 9.12% in treated, T2 sample as compared to the control. However, the isotopic abundance ratio of (PM+2)/PM in 4-bromoacetophenone was decreased from 0.1 to 1.62% in T1 to T4 samples, as compared to the control. The biofield treatment may have altered the isotopic abundance ratio of (PM+1)/PM and (PM+2)/PM of treated 4-bromoacetophenone from the control sample. Furthermore, it is assumed that the lower isotopic ratio of (PM+1)/PM and (PM+2)/PM, might have decreased the stability of the compound due to the decreased µ (reduced mass) and binding energy in molecules with lighter isotopic bonds. This lower binding energy may lead to decrease the bond strength for treated 4-bromoacetophenone, however, the reverse might happen in treated T3 sample [20 ]. It is reported that the isotope fractionation for bromine and oxygen is slower than chlorine, carbon, hydrogen, and nitrogen, which is much dependent on the reaction path (kinetic) of organohalogen compounds [21 ], and we have observed a slow depletion of (PM+2)/PM ratio (1.62%). Thus, GC-MS data suggested that biofield treatment has significantly altered the isotopic ratio of in treated 4-bromoacetophenone molecule.

Fig. 4(a). GC-Mass spectra of control sample of 4-bromoacetophenone.

Fig. 4(b). GC-MS spectra of treated (T1, T2, T3 and T4) samples of 4-bromoacetophenone.

Fig. 5. Percent change in isotopic abundance ratio of (PM+1)/PM and (PM+2)/PM in treated samples of 4-bromoacetophenone.

Table 3. GC-MS isotopic abundance analysis result of 4-bromoacetophenone.

Fig. 6. UV-Vis spectra of control and treated 4-bromoacetophenone sample.

3.6. UV-Vis Analysis

The UV spectra of control and treated 4-bromoacetophenone are shown in Figure 6. The UV spectrum of control sample showed the absorbance maxima (λmax ) at 205 and 254 nm. Similarly, the spectra of treated sample showed the λmax at 203 and 254 nm. The peak at 254 nm absorption maximum in control sample did not show any shift of wavelength after biofield energy treatment. However, the peak at higher energy region showed a minor blueshift from 205 nm (control) to 203 nm (treated). The result showed that similar pattern but a minor shift of absorbance maxima was exibited by the treated sample as compared to the control. Therefore, it is suggested that the biofield treatment did not disturb the HOMO-LUMO energy gap in the treated sample as compared to the control.

In summary, the crystallite size was significantly decreased by 16.69% with decreased intensity of the diffractogram in treated 4-bromoacetophenone as compared to the control. The melting point, latent heat of fusion, and Tmax were decreased slightly by 1.42 %, 0.85 %, and 7.26%, respectively in the treated sample as compared to the control, indicated the reduced thermal stability of the biofield treated 4-bromoacetophenone. The isotopic abundance ratio of (PM+1)/PM of treated 4-bromoacetophenone was significantly decreased to 9.12% in T2 and slight increased up to 3.83 % in T3 sample as compared to the control. However, the isotopic abundance ratio of (PM+2)/PM in treated 4-bromoacetophenone was decreased by 1.62%. It is assumed that due to the lowering of isotopic abundance ratio of (PM+1)/PM and (PM+2)/PM of treated 4-bromoacetophenone, with lower binding energy may lead to lowering of chemical stability than the control sample. The lowering of isotopic abundance is well corroborated with the shifting of C=O and C=C peak to higher wavenumber region in FT-IR spectra. It is assumed that the lowering of thermal stability in treated 4-bromoacetophenone could make it useful as a reaction intermediate in various coupling reactions and in the synthesis of polymers.

XRD: X-ray diffraction

FT-IR: Fourier transform infrared

GC-MS: Gas chromatography-mass spectrometry

DSC: Differential scanning calorimetry

TGA: Thermogravimetric analysis

PM: Primary mass (m/z = 198 for 4-bromoacetophenone)

PM+1: represents isotopic molecule (m/z = 199)

PM+2: represents isotopic molecule (m/z = 200)

The authors would like to acknowledge the whole team of MGV Pharmacy College, Nashik for providing the instrumental facility. We would also like to thank Trivedi Science TM. Trivedi Master Wellness TM and Trivedi Testimonials for their support during the work.

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3 bromoacetophenone synthesis essay

3'-Bromoacetophenone Hot Products 3'-Bromoacetophenone Specification

The 3'-Bromoacetophenone, with the CAS registry number 2142-63-4, is also known as m-Bromoacetophenone. It belongs to the product categories of Carbonyl Compounds; Halides; Aromatic Acetophenones & Derivatives (substituted); Benzene series; API intermediates; Adehydes, Acetals & Ketones; Bromine Compounds; Acetophenone series; Building Blocks; C7 to C8; Chemical Synthesis; Ketones; Organic Building Blocks. Its EINECS number is 218-396-0. This chemical's molecular formula is C8 H7 BrO and molecular weight is 199.05. What's more, its systematic name is 1-(3-Bromophenyl)ethanone. This chemical should be sealed and stored in a cool and dry place. Moreover, it should be protected from oxides. It is used as synthetic material of organic chemical.

Physical properties of 3'-Bromoacetophenone are: (1)ACD/LogP: 2.47; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.47; (4)ACD/LogD (pH 7.4): 2.47; (5)ACD/BCF (pH 5.5): 44.38; (6)ACD/BCF (pH 7.4): 44.38; (7)ACD/KOC (pH 5.5): 525.63; (8)ACD/KOC (pH 7.4): 525.63; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 17.07 Å 2 ; (13)Index of Refraction: 1.554; (14)Molar Refractivity: 43.971 cm 3 ; (15)Molar Volume: 137.149 cm 3 ; (16)Polarizability: 17.431×10 -24 cm 3 ; (17)Surface Tension: 39.1 dyne/cm; (18)Density: 1.451 g/cm 3 ; (19)Flash Point: 90.945 °C; (20)Enthalpy of Vaporization: 49.266 kJ/mol; (21)Boiling Point: 255.203 °C at 760 mmHg; (22)Vapour Pressure: 0.02 mmHg at 25°C.

Preparation: this chemical can be prepared by 1-(3-bromo-phenyl)-ethanol at the ambient temperature. This reaction will need reagent CrO3 -"wet-Alumina" and solvent hexane with the reaction time of 24 hours. The yield is about 96%.

Uses of 3'-Bromoacetophenone: it can be used to produce 1-(3-bromo-phenyl)-3-pyridin-2-yl-propenone by heating. The reaction time is 25 min. The yield is about 64%.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing and you must avoid contact with skin and eyes.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(c1cc(Br)ccc1)C
(2)Std. InChI: InChI=1S/C8H7BrO/c1-6(10)7-3-2-4-8(9)5-7/h2-5H,1H3
(3)Std. InChIKey: JYAQYXOVOHJRCS-UHFFFAOYSA-N

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